Efek Lactobacillus rhamnosus dan Bifidobacterium bifidum Terhadap Kolesterol Tikus Putih Yang di Induksi High Fat Diet

Kadeq Novita Prajawanti

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Pengobatan utama untuk hiperlipidemia adalah diet dan modifikasi gaya hidup, diikuti terapi obat apabila diperlukan. Pendekatan biologis seperti konsumsi probiotik atau makanan fungsional yang mengandung probiotik, yang murah dan aman dalam aplikasi jangka panjang mulai diteliti. Penelitian ini bertujuan untuk mengetahui efek pemberian kombinasi probiotik Lactobacillus rhamnosus dan Bifidobacterium bifidum terhadap kadar kolesterol tikus putih (Rattus norvegicus) yang diinduksi High Fat Diet. Jenis penelitian ini adalah True Experimental dengan menggunakan rancangan penelitian Pre-Post Test Group Design. Untuk mengetahui perbedaan secara umum rerata kadar kolesterol pada tiap kelompok dilakukan dengan Uji Paired-Sample T Test (p<0,05). Pemberian kombinasi Lactobacillus rhamnosus dan Bifidobacterium bifidum dengan kepadatan 1x1010 CFU/mL dan ragam dosis pemberian 2mL, 2,5mL dan 3mL mampu menurunkan kadar kolesterol tikus yang diinduksi high fat diet.

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DOI: http://dx.doi.org/10.36434/scientia.v10i1.255

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