UJI EFEK ETANOL DAUN BENALU BATU TERHADAP KREATININ UREUM TIKUS PUTIH JANTAN DIINDUKSI STREPTOZOTOCIN

Syafika Alaydrus

Sari


This study aims to determine the content of secondary metabolites in the ethanol extract of the  begonia leaves, the effect of the extract and the effective dose of in blood urea and creatinine levels, the study is a laboratory experiment using a modified pretest and posttest randomized controlled group design. 25 rats as animal test were divided into 5 treatment groups, namely normal control, negative control, a dose of 50, 100 and 200 mg/kgBW. The result showed that the ethanol extract of the  begonia leaves contained secondary metabolites of flavonoid, alkaloid, saponin and tannin compounds; ethanol extract of parasites of rock leaves gave an effect on decreasing blood urea and creatinine levels; ethanol extract of  begonia at a dose of 100 mg/kgBW is an effective dose in reducing blood creatinine and ureum has no effect levels with an average value creatinine 0.485/dL


Kata Kunci


begonia leaves, urea, creatinine, streptozotocin

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Referensi


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DOI: http://dx.doi.org/10.36434/scientia.v10i1.315

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