FORMULATION OF EEL (MONOPTERUS ALBUS) EXTRACT GELS FOR ACCELERATED THE WOUND HEALING

Febriyenti Febriyenti

Sari


Eel contains a lot of amino acids and fatty acids that play an important rule in wound healing processes.  This study aims to formulate the eel extract gel to accelerate burn wounds healing. Polyvinyl alcohol (PVA) 146,000 and hydroxypropylmethyl cellulose (HPMC) 60SH-50 were used as gelling agents. Each gelling agent was used in three different concentrations i.e. PVA with concentration 8% (FA1), 10% (FA2) and 12% (FA3); HPMC with concentration 4% (FB1), 5% (FB2) and 6% (FB3). Propylene glycol was used as a humectant. Methylparaben and propylparaben were used as preservatives. Vitamin E was used as an antioxidant. Evaluations included general appearance, homogeneity, pH, washed test, and viscosity. The best formula is then tested for its effect on the healing of burn wounds. The results showed that formula that used PVA as a gelling agent produced transparent gel, while the formula that used HPMC produced opaque gel. Increasing the gelling agent concentration, increasing the viscosity of the gel produced. According to the physical appearance of the gel produced a formula that used PVA 10% (FA2) as the gelling agent was the best formula among the other formulas. From the results of tests on burns healing, gel formulas containing eel extract heal wounds faster than base gel and positive control.


Kata Kunci


Eel (Monopterus albus) extract, gel, wound healing, burn wound

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DOI: http://dx.doi.org/10.36434/scientia.v10i2.350

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