Budi Setiawan, Erizal Zaini, Salman Umar


A study on the solid dispersion system of Acyclovir with poloxamer 188 has been conducted a
physical mixture formulation with a ratio of 1 : 1, 1 : 3, 1 : 5 and solid dispersion 1 : 1, 1 : 3, 1 : 5 and cogrinding
1 : 1 as a comparison. Solid dispersions made by the method of melting (fusion), which merged
with poloxamer 188 on the hot plate then acyclovir incorporated into the fused results in poloxamer 188
while stirring to form a homogeneous mass. All formulas are formed including poloxamer 188 acyclovir
pure and good analysis that test kerakterisasi with Differential Thermal Analysis (DTA), X-ray
Diffraction, Scanning Electron Microscopy (SEM), and Fourier Transform Infrared (FTIR), then
performed retrieval (determination levels) by UV spectrophotometry at a wavelength of 257.08 nm and
dissolution rate test with CO2-free aquadest using the paddle method. Retrieval results (determination of
Kedar) found that all formulas meet the requirements set forth in United States Pharmacopeia 30, and the
fourth edition of the Pharmacopoeia Indonesia 95-110%. While the dissolution rate test results for a
physical mixture of 1 : 1, and solid dispersion 1 : 1, and co-grinding 1 : 1 experienced a significant
increase when compared with pure Acyclovir. It also can be seen from the results of the statistical
calculations using one-way analysis of variance SPSS 17.

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