PENINGKATAN LAJU DISOLUSI ACYCLOVIR DENGAN METODE SISTEM DISPERSI PADAT MENGGUNAKAN POLOXAMER 188

Budi Setiawan, Erizal Zaini, Salman Umar

Sari


A study on the solid dispersion system of Acyclovir with poloxamer 188 has been conducted a
physical mixture formulation with a ratio of 1 : 1, 1 : 3, 1 : 5 and solid dispersion 1 : 1, 1 : 3, 1 : 5 and cogrinding
1 : 1 as a comparison. Solid dispersions made by the method of melting (fusion), which merged
with poloxamer 188 on the hot plate then acyclovir incorporated into the fused results in poloxamer 188
while stirring to form a homogeneous mass. All formulas are formed including poloxamer 188 acyclovir
pure and good analysis that test kerakterisasi with Differential Thermal Analysis (DTA), X-ray
Diffraction, Scanning Electron Microscopy (SEM), and Fourier Transform Infrared (FTIR), then
performed retrieval (determination levels) by UV spectrophotometry at a wavelength of 257.08 nm and
dissolution rate test with CO2-free aquadest using the paddle method. Retrieval results (determination of
Kedar) found that all formulas meet the requirements set forth in United States Pharmacopeia 30, and the
fourth edition of the Pharmacopoeia Indonesia 95-110%. While the dissolution rate test results for a
physical mixture of 1 : 1, and solid dispersion 1 : 1, and co-grinding 1 : 1 experienced a significant
increase when compared with pure Acyclovir. It also can be seen from the results of the statistical
calculations using one-way analysis of variance SPSS 17.


Teks Lengkap:

PDF PDF (English)

Referensi


Abdou, H. M. (1989). Dissolution, Biovability and Bioeqivalency. Pennsylvania : Mack Publishing Company.

Ansel, H.C. (1989). Pengantar Bentuk Sediaan Farmasi (Edisi IV). Penerjemah:F. Ibarahim. Jakarta : UI Press.

Ainley, W & P. J. Weller, 1994, HandBook of Pharmaceutical Excipient, Second edition. The Pharmaceutical Press, London.

Departemen Kesehatan RI (1995). Farmakope Indonesia, Ed IV., Direktorat Jendral Pengawasan Obat dan Makanan, Jakarta.

Grag, A., Singh, S., Rao, V. U., Bindu, K., & Balasubramaniam, J. (2009). Solid state interaction of raloxifene HCl with different hydrophilic carriers during cogrinding and its effect on dissolution rate, Drug Development Industrial Pharmacy, 35, 455-470.

Neha, Preeti, C., Atin, K., Rajan, P., Kumar, M. R., Santanu, M., Pardeep, K., Munsab, A., & Shamin, A. (2012). Approaches to improve the solubility and bioavaibility of poorly soluble drugs and different

parameter to screen them, Novel Science International Journal of Pharmaceutical Science, 1(4), 498-502.

Rowe, R. C, Paul J.S, Sian C.O (2006). Handbook of Pharmaceutical Excipient, (5 th Ed). London : The Pharmaceutical Press.

Sahoo S,Chakraborti CK, Mishra SC, Nanda UN, Naik S. (2011). FTIR and XRD investigations of some Fluoroquinolones. Int J Pharmacy Pharm Sci; 3(3): 165-70.

Shargel, L., B. C. Yu and Adrew. (1988).Biofarmasetika Farmakokinetika

Serapan (Edisi 2 ). Penerjemah : Fasich. Surabaya : Unair Press.

Swarbick, J., and James, C. B. (1990). Copresipitates and Melt. Encyclopedia of Pharmaceutical Tecnology vol 3, New York : Marcell Dekker hc.

The United State Pharmacopeia Convention. (2007). The official compendia of standards United States Pharmacopeia 30 – national formulary 25. New York: USP Convention.

Voigt, R. (1994). Buku Pelajaran Teknologi Farmasi. (edisi V). Penerjemah: Noerono, S. Yogyakarta: Gajah Mada University Press.

Zaini, E., Sumirtaputra, Y.C., Soewandhi, S.N., and Halim, A. (2008). Formation ofCocrystal between Trimethoprim and Sulfamehtoxazole by Solid State Grinding. Proceeding Asean Scientific Conference in Pharmaceutical Technology, USM Penang-Malaysia.




DOI: http://dx.doi.org/10.36434/scientia.v5i1.61

Refbacks

  • Saat ini tidak ada refbacks.


SCIENTIA Jurnal Farmasi dan Kesehatan

diterbitkan oleh STIFI Perintis Padang

Jl. Adinegoro km 17/Simp. Kalumpang Lubuk Buaya Padang – 25173

Telp. (0751) 482171  Fax. (0751)484522

    p-ISSN : 2087-5045                 e-ISSN : 2502-1834

       

 
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.